Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition
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چکیده
منابع مشابه
Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens.
1. The diversity of alpha(2) and purinergic autoreceptor actions on action potential evoked calcium transients in single varicosities has been investigated using the calcium indicator Oregon Green 488 BAPTA-1. 2. During long trains of impulses (10 Hz for 30 s), the change in calcium concentration in varicosities from its resting level (Delta[Ca(2+)](v)) increased in many varicosities during the...
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The postganglionic axons of sympathetic neurons innervating the mouse vas deferens were stimulated transmurally in vitro by passing square pulses between two platinum electrodes. The ultrastructural appearance of the adrenergic nerve terminals was compared to samples fixed immediately after 30 min of stimulation and in samples allowed to recover for 2 h before fixation. The contralateral vasa d...
متن کاملThe University of Birmingham Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens
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This study was undertaken to explore the spinal cord segments controlling the canine and human vas deferens and differentiation of the mammalian sympathetic pathways to the vas deferens. Thoracolumbar white communicating rami (WCR) were electrically stimulated in the dogs. Stimulation of the 1st, 2nd, 3rd, and 4th lumbar WCR elicited an elevation of intraluminal pressure of the vas deferens in ...
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The vas deferens has been used as a model for many diverse studies of different aspects of autonomic neurotransmission since its introduction including, in particular, sympathetic cotransmission involving release of ATP and neuropeptide Y together with noradrenaline and prejunctional and postjunctional neuromodulation. It has also been used to study sympathetic reinnervation following vasectomy...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1997
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1997.521bj.x